Passiflora quadrangularis, popularly known as melon passion fruit, is a fruit-bearing vine native to the tropical regions of the Americas, with diverse uses and benefits, both in food and traditional medicine. The fruits of the melon passion fruit are edible and can be consumed fresh, in juices, jams, sweets, and other culinary preparations. The fruit pulp is rich in vitamins (especially vitamin C), minerals, and fiber. It has a sweet taste. • Traditional medicine: In folk medicine, melon passion fruit is used to treat digestive problems, insomnia, and anxiety. Scientific studies have shown that the plant has sedative, anxiolytic, and anti-inflammatory properties. • Other uses: The leaves of the plant are used to prepare medicinal teas. The plant also has ornamental uses. Main medicinal uses: Natural calming agent and anxiety relief. The best-known medicinal use of the giant passion fruit is its action on the nervous system. Leaves and flowers are traditionally used to help with: Anxiety, Nervousness, Agitation, Emotional stress, Irritability. Several studies with Passiflora species indicate anxiolytic activity related to the flavonoids present in the plant. Sleep disorders. Infusions of the leaves are popularly used for: Mild insomnia, Restless sleep, Difficulty falling asleep, Frequent awakenings. Its effect is generally considered mild, promoting relaxation without causing intense sedation. Cardiovascular health. The fruit is rich in: Potassium, Magnesium, Fiber, Antioxidant compounds. These nutrients can contribute to: Blood pressure control, Vascular health, Reduction of oxidative stress, Anti-inflammatory action. Leaves, bark, and fruits contain phenolic compounds that have shown anti-inflammatory activity in experimental studies. Traditionally used for: Muscle pain. Mild inflammations. Joint discomfort. Digestive health. The pulp contains fiber that helps: Intestinal transit. Intestinal microbiota. Prevention of constipation. In some regions, an infusion of the leaves is also used to relieve cramps and digestive discomfort. External use. Poultices prepared with fresh leaves are popularly used for: Minor skin inflammations. Insect bites. Skin irritations.